Human Pharma

Affects My
Entire Life

Generalized Pustular Psoriasis (GPP) is a rare heterogeneous and potentially life-threatening skin disease. It causes painful sterile pustules all over the body. So far, little is known about living with this disease.

What causes

The exact cause of GPP is unknown, but factors that can trigger GPP flares include: overexposure to sunlight, genetic mutations, sudden withdrawal of steroids, and exposure to certain medications, hormonal changes and pregnancy, periods of stress and anxiety, dental or upper respiratory tract infections.

Twice as many women as men are impacted by GPP, but it can affect anyone. GPP often starts in people in their 40s but can occur at a younger age, although this is less common.

Symptoms Include:

Episodes or flares of widespread reddened, inflamed skin covered with painful pus-filled blisters – with or without general symptoms such as fever, joint pain, or extreme tiredness.


GPP is an immune disease and not contagious.


GPP flares can come on very suddenly at any time. It is hard to know when it appears and how long it will last. If untreated, it can be life-threatening.